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Calliope Jo Prudence Plein

Mastiff

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“Callie was adopted from Capital Humane Society at 8 weeks old. Her parents were strays that were never reclaimed. DOB is 12-5-19. Callie is sweet, calm, sensitive, and friendly. She enjoys following her nose but will listen when she is told to leave it. She enjoys swimming, the dog park, and going on walks on various trails. She is an expert napper and will stare at me when it is time for bed, demanding that she needs to cuddle to sleep.”

Place of Birth

Lincoln, NE, USA

Current Location

Manhattan, Kansas, USA

From

Lincoln, NE, USA

This dog has been viewed and been given 20 wags

Genetic Breed Result

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Mastiff

Mastiffs are large but lovable dogs, known for their friendly and protective family characteristics.

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Calliope Jo Prudence Plein’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Calliope Jo Prudence Plein is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Canine Multifocal Retinopathy, cmr1

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Calliope Jo Prudence Plein inherited both copies of the variant we tested

How to interpret this result

Calliope Jo Prudence Plein has two copies of a variant in the BEST1 gene and is at risk for developing CMR. Please consult your veterinarian regarding an ophthalmologic exam and other diagnostics for Calliope Jo Prudence Plein.

What is Canine Multifocal Retinopathy, cmr1?

This is a non-progressive retinal disease that, in rare cases, can lead to vision loss. Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

Degenerative Myelopathy, DM

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Calliope Jo Prudence Plein inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Calliope Jo Prudence Plein is unlikely to develop this condition due to the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Breed-Relevant Genetic Conditions

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Autosomal Dominant Progressive Retinal Atrophy

Identified in Mastiffs

Urate Kidney & Bladder Stones

Identified in Mastiffs

Additional Genetic Conditions

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Clinical Tools

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Explore the genetics behind your dog’s appearance and size.

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Base Coat Color

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Through Calliope Jo Prudence Plein’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A382

Map

A1a

Calliope Jo Prudence Plein’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A382

Calliope Jo Prudence Plein’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Labrador Retrievers, Golden Retrievers, and Chesapeake Bay Retrievers.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Calliope Jo Prudence Plein inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Calliope Jo Prudence Plein is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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