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Buddy

Mixed Ancestry

“Found starving dehydrated 35 pounds under weight eating out of a dumpster behind a store with infected cut paw & road asphalt stuck to his coat & paws. Very bad heart worms. But still a happy loving dog. Now a very strong 95 lbs no heart worms. Dog & people friendly working on cats. Wants & needs constant loving & contact. Just wants to be with me all the time. Already saved me from a rattlesnake. Some reason like to trail snakes. See pic of snake. Hangs out with his RedNose pitbull buddy Jack”

Place of Birth

Hardeeville, South Carolina, USA

Current Location

Hardeeville, South Carolina, USA

From

Hardeeville, South Carolina, USA

This dog has been viewed and been given 111 wags

Registration

Microchip: No

Genetic Breed Result

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American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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American Bulldog

American bulldogs are enjoying a healthy increase in popularity, either as a working/protector dog or as a family pet. All over the world, they are used variously as "hog dogs" (catching escaped pigs or hunting razorbacks), as cattle drovers and as working or sport K-9s. American Bulldogs also successfully compete in several dog sports such as dog obedience, Iron Dog competition and weight pulling.

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Bulldog

Originally a bull-baiting dog, bulldogs today are gentle and loving while still carrying the stocky frame of their forbearers.

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Dogs Like Buddy

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Discover dogs who share a similar breed mix to Buddy. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
American Pit Bull Terrier
American Bulldog
Bulldog

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Health Summary

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Buddy inherited three variants that you should learn more about.

And one variant that you should tell your vet about.

Progressive Retinal Atrophy, crd4/cord1

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Buddy inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Buddy’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Buddy is unlikely to develop this condition due to this variant because he only has one copy of the variant.

What is Progressive Retinal Atrophy, crd4/cord1?

PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.

Enamel Hypoplasia

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Buddy inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Buddy’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Buddy is unlikely to develop this condition due to this variant because he only has one copy of the variant.

What is Enamel Hypoplasia?

In ARAI, a defect in enamel production leads uneven enamel lay down, leading to yellowing of the underlying tooth. Teeth are also unusually small and pointy with large gaps between them.

Degenerative Myelopathy, DM

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Buddy inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Buddy’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Buddy is unlikely to develop this condition due to this variant because he only has one copy of the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Buddy inherited one copy of the variant we tested

Why is this important to your vet?

Buddy has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Buddy has this genotype, as ALT is often used as an indicator of liver health and Buddy is likely to have a lower than average resting ALT activity. As such, an increase in Buddy’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers

Progressive Retinal Atrophy, crd2

Identified in American Pit Bull Terriers

Canine Multifocal Retinopathy, cmr1

Identified in American Bulldogs and Bulldogs

Urate Kidney & Bladder Stones

Identified in American Pit Bull Terriers, American Bulldogs, and more

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers

Neuronal Ceroid Lipofuscinosis 10, NCL 10

Identified in American Bulldogs

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers

Ichthyosis

Identified in American Bulldogs

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Buddy’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A247

Map

A1d

Buddy’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A247

Buddy’s Haplotype

Part of the large A1d haplogroup, this common haplotype occurs in village dogs all over the world. Among the 32 breeds we have sampled it in, the most common occurrences include Boxers, Labrador Retrievers, and Papillons.

The vast majority of Rottweilers have the A1d haplogroup.

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Through Buddy’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H7.1/6/7

Map

D

Buddy’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H7.1/6/7

Buddy’s Haplotype

Part of the D haplogroup, this haplotype occurs most frequently in mixed breed dogs.

The D paternal lineage is common in Boxers.

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