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Bryn

Golden Retriever

“She has the best eyes. They are so expressive and amazing. They add to her incredibly sensitive and sweet personality.”

Place of Birth

Bellingham, WA, USA

Current Location

Blaine, WA, USA

From

Bellingham, WA, USA

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Registration

American Kennel Club (AKC):

Genetic Breed Result

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Golden Retriever

Developed as an ideal hunting retriever, the Golden Retriever's eagerness to please and friendliness has made them an extremely popular family pet.

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Here’s what Bryn’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Bryn’s breed mix.
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Health Summary

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Bryn is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Ichthyosis, ICH1

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Bryn inherited both copies of the variant we tested

How to interpret this result

Bryn has two copies of a variant at PNPLA1 and is at risk for developing ichthyosis. Please consult your veterinarian to discuss further diagnostics, treatment, and care for this condition.

What is Ichthyosis, ICH1?

This skin disorder gets its name from the thick, darkly pigmented scales of skin ("ichthys" is Greek for "fish") that affected dogs display over most areas of the body, not including the head or extremities.

ALT Activity

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Bryn inherited one copy of the variant we tested

Why is this important to your vet?

Bryn has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Bryn has this genotype, as ALT is often used as an indicator of liver health and Bryn is likely to have a lower than average resting ALT activity. As such, an increase in Bryn’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1

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Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Golden Retrievers

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Golden Retrievers

Degenerative Myelopathy, DM

Identified in Golden Retrievers

Muscular Dystrophy

Identified in Golden Retrievers

Dystrophic Epidermolysis Bullosa

Identified in Golden Retrievers

Osteogenesis Imperfecta

Identified in Golden Retrievers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Bryn’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A399

Map

A1a

Bryn’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A399

Bryn’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in Golden Retrievers.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Bryn inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Bryn is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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