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Brutus

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Health Summary

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Brutus inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Ichthyosis, ICH1

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Brutus inherited one copy of the variant we tested

What does this result mean?

This result should not impact Brutus’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring.

What is Ichthyosis, ICH1?

This skin disorder gets its name from the thick, darkly pigmented scales of skin ("ichthys" is Greek for "fish") that affected dogs display on their noses, paw pads, and muzzles.

ALT Activity

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Brutus inherited one copy of the variant we tested

Why is this important to your vet?

Brutus has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Brutus has this genotype, as ALT is often used as an indicator of liver health and Brutus is likely to have a lower than average resting ALT activity. As such, an increase in Brutus’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1 (SLC4A3)

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)

Identified in Golden Retrievers

Neuronal Ceroid Lipofuscinosis 5, NCL 5 (CLN5 Exon 4 Deletion, Golden Retriever Variant)

Identified in Golden Retrievers

Degenerative Myelopathy, DM (SOD1A)

Identified in Golden Retrievers

Muscular Dystrophy (DMD, Golden Retriever Variant)

Identified in Golden Retrievers

Congenital Myasthenic Syndrome, CMS (COLQ, Golden Retriever Variant)

Identified in Golden Retrievers

Dystrophic Epidermolysis Bullosa (COL7A1, Golden Retriever Variant)

Identified in Golden Retrievers

Osteogenesis Imperfecta (COL1A1, Golden Retriever Variant)

Identified in Golden Retrievers

Additional Genetic Conditions

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