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Brumby

Mixed Ancestry

“She was feral caught, near San Antonio, Texas. She was sent to me around 5/6 months old, to Washington state. She is now my Service Dog, and we have traveled as far as Fairbanks, Alaska, in three layers of clothes and boots in -50 degree weather! She’s been to the circus, professional drifting events, horse shows, musicals, and more! She loves to work, and also helps her humans to train OTHER dogs!”

Place of Birth

San Antonio, TX, USA

Current Location

Monroe, Washington, USA

From

San Antonio, TX, USA

This dog has been viewed and been given 21 wags

Registration

Microchip: 985112010468628

Genetic Breed Result

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German Shepherd Dog

German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence. These are active working dogs who excel at many canine sports and tasks -- they are true utility dogs! Their versatility combined with their loyal companionship has them consistently listed as one of the most popular breeds in the United States.

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American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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American Staffordshire Terrier

American Staffordshire Terriers are powerful but playful dogs that are both loyal and affectionate with their owners.

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Dogs Like Brumby

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Discover dogs who share a similar breed mix to Brumby. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
German Shepherd Dog
American Pit Bull Terrier
American Staffordshire Terrier

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Changes to this dog’s profile
  • On 6/26/2020 changed handle from "brumby3" to "brumby18"
Here’s what Brumby’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Brumby’s breed mix.

Breed Reveal Video

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Health Summary

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Brumby inherited two variants that you should learn more about.

And one variant that you should tell your vet about.

Urate Kidney & Bladder Stones

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Brumby inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Brumby’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Brumby is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

Protein Losing Nephropathy, PLN

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Brumby inherited one copy of the variant we tested

What does this result mean?

We do not know whether this increases the risk that Brumby will develop this disease.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with the breeds in Brumby have been studied to know whether or not this variant will increase Brumby’s risk of developing this disease.

What is Protein Losing Nephropathy, PLN?

Protein Losing Nephropathy causes inappropriate loss of protein in the urine. Certain parts of the kidney act as a sieve where ions, small molecules like urea, and water are filtered out of the blood into the urine. In PLN, the sieve is compromised and protein moves in the urine. This leads to muscle wasting, abnormal fluid accumulation in the skin and limbs, and kidney failure.

ALT Activity

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Brumby inherited one copy of the variant we tested

Why is this important to your vet?

Brumby has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Brumby has this genotype, as ALT is often used as an indicator of liver health and Brumby is likely to have a lower than average resting ALT activity. As such, an increase in Brumby’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III

Identified in German Shepherd Dogs

Platelet Factor X Receptor Deficiency, Scott Syndrome

Identified in German Shepherd Dogs

Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers and American Staffordshire Terriers

Day Blindness

Identified in German Shepherd Dogs

Anhidrotic Ectodermal Dysplasia

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII

Identified in German Shepherd Dogs

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers and American Staffordshire Terriers

Degenerative Myelopathy, DM

Identified in German Shepherd Dogs

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers and American Staffordshire Terriers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

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Through Brumby’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A377

Map

A1a

Brumby’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A377

Brumby’s Haplotype

Part of the large A1a haplogroup, this rare haplotype occurs in dogs with European ancestry.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Brumby inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Brumby is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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