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“Franklin”
Essence Of Grace Franklin

Yorkshire Terrier

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“First born tiny of the litter”

Place of Birth

Torrance, CA, USA

Current Location

Torrance, CA, USA

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Registration

American Kennel Club (AKC):

Genetic Breed Result

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Yorkshire Terrier

Petite but proud, the Yorkshire terrier is a popular toy breed with a silky, low-shedding coat.

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Genetic Stats

Predicted Adult Weight

5 lbs

Genetic Age
17 human years

Based on the date of birth provided

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Changes to this dog’s profile
  • On 7/29/2022 changed name from "Pepper" to "Essence Of Grace Franklin"
  • On 3/13/2022 changed name from "Boy #1 tiny boy" to "Pepper"

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Health Summary

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Franklin inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Dilated Cardiomyopathy, DCM1

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Franklin inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Franklin will develop this condition.

Scientific Basis

Dogs with Franklin’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Franklin developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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Franklin inherited one copy of the variant we tested

Why is this important to your vet?

Franklin has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Franklin has this genotype, as ALT is often used as an indicator of liver health and Franklin is likely to have a lower than average resting ALT activity. As such, an increase in Franklin’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Yorkshire Terriers

Primary Lens Luxation (ADAMTS17)

Identified in Yorkshire Terriers

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Franklin’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A652

Map

A1e

Essence Of Grace Franklin’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A652

Essence Of Grace Franklin’s Haplotype

Part of the A1e haplogroup, the A652 haplotype occurs most commonly in Chihuahuas.

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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Through Franklin’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.27

Map

A1a

Essence Of Grace Franklin’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.27

Essence Of Grace Franklin’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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