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“Mac”
Bonnybrooke's Macintosh Apple of Her Eye CGC CGCA CGCU DM RATI AS DSA RATN URO1 DDB ORT

English Shepherd

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“Mac is my constant companion and my dog sport partner. He's happy-go-lucky, extremely athletic, and loves to work. He is a 42# intact male. We participate together in disc, dock diving, nosework, barn hunt, agility, rally obedience, lure coursing, herding, canicross, hiking, and trick training.”

Instagram tag
@mac.on.trail

Place of Birth

Cleveland, SC, USA

Current Location

Auburn, Alabama, USA

This dog has been viewed and been given 4 wags

Registration

English Shepherd Club (ESC): ESC-4896
Microchip: 985112004868118

Genetic Breed Result

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English Shepherd

A farmer's helper, a loyal companion, a child's shadow: The English Shepherd.

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Genetic Stats

Predicted Adult Weight

64 lbs

Genetic Age
48 human years

Based on the date of birth provided

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Health Summary

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Mac is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Collie Eye Anomaly

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Mac inherited both copies of the variant we tested

How to interpret this result

Mac has two copies of a mutated allele at the NHEJ1 gene and is at high risk for developing Collie Eye Anomaly. Please consult with your veterinarian to develop a diagnostic and monitoring plan for Mac.

What is Collie Eye Anomaly?

Named for its high prevalence in Collie dogs, Collie Eye Anomaly (CEA) is more correctly termed choroidal hypoplasia. The choroid anchors the retina to the underlying structures and supplies it with oxygen and nourishment. CEA is a developmental disease of the choroid.

Degenerative Myelopathy, DM

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Mac inherited both copies of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Mac will develop this condition.

Scientific Basis

Dogs with Mac’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Mac developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Dilated Cardiomyopathy, DCM1

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Mac inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Mac will develop this condition.

Scientific Basis

Dogs with Mac’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Mac developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in English Shepherds

Trapped Neutrophil Syndrome, TNS (VPS13B)

Identified in English Shepherds

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in English Shepherds

Urate Kidney & Bladder Stones (SLC2A9)

Identified in English Shepherds

Additional Genetic Conditions

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Clinical Tools

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (Ee)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
Intensity Loci LINKAGE
Any light hair likely yellow or tan (Intermediate Red Pigmentation)
A Locus (ASIP)
Fawn Sable coat color pattern (ayat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Not expressed (NI)
S Locus (MITF)
Likely to have little to no white in coat (SS)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely long coat (TT)
Shedding (MC5R)
Likely heavy/seasonal shedding (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Smaller (II)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Smaller (AA)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Mac’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B43

Map

B1

Bonnybrooke's Macintosh Apple of Her Eye’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B43

Bonnybrooke's Macintosh Apple of Her Eye’s Haplotype

Part of the large B1 haplogroup, we have spotted this haplotype in Havanese, Cocker Spaniels, and village dogs in Mexico.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Mac’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.53

Map

A1a

Bonnybrooke's Macintosh Apple of Her Eye’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.53

Bonnybrooke's Macintosh Apple of Her Eye’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in Golden Retrievers, Border Collies, and the Coton de Tulear.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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