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“Nala Blue”
Nala Blue von WinterKommT

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See what’s hidden in the pages of Nala Blue’s DNA story.

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Genetic Breed

German Shepherd Dog

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Genetic Stats

Wolfiness: 0.3 % LOW
Predicted Adult Weight: 69 lbs
Genetic Age: 16 human years

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Health

>
We have tested Nala Blue for over 160 genetic health conditions to alert her owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Nala Blue.

Maternal Haplotype

>
Through the DNA inherited from Nala Blue’s mother we can trace her ancestry back to where dogs and people first became friends. Find out how far Nala Blue’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Nala Blue’s DNA includes a story of where her father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

Let us know and we will contact Nala Blue’s owner and make sure she is reunited with her family soon! Thank you for helping out our furry friends.

What’s your dog’s story?

Now that you have explored what’s behind Nala Blue find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Changes to this dog’s profile
  • On 1/18/2018 changed name from "Blue von WinterKommT" to "Nala Blue von WinterKommT"
What’s this?

Summary

0
AT RISK
0
CARRIER
165
CLEAR
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Clinical traits

These genetic traits are valuable to your veterinarian and can inform the clinical decisions and diagnoses they make.

Alanine Aminotransferase Activity result: Normal
Known to be highly expressed in liver cells, activity levels of alanine aminotransferase, or ALT, is a common value on most blood chemistry panels and is known to be a se…
Nala Blue von WinterKommT has two normal alleles at ALT.

Not At Risk

Good news! Nala Blue did not test positive for any of the genetic diseases that Embark screens for. Read on to learn more about the conditions we test for, but rest assured that Nala Blue does not have the mutations known to cause them.

It is still important to let your veterinarian know these results because they could help guide Nala Blue’s diagnosis and treatment if she gets sick in the future. Many other diseases caused by environmental factors or undiscovered genetic variants can cause symptoms similar to diseases we test for. By ruling out these mutations, your veterinarian will be able to find the true cause more quickly. Your veterinarian will also know they can safely prescribe medications some dogs are sensitive to.

Not A Carrier

Good news! Nala Blue is not a carrier for any of the genetic diseases that Embark tests for.

Common Conditions

Good news! Nala Blue tested clear for 10 genetic conditions that are common in her breed.
Condition List

MDR1 Drug Sensitivity
(MDR1)
Clinical

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with mutatio…

Factor VIII Deficiency, Hemophilia A
(F8 Exon 11, Shepherd Variant 1)
Blood

Coagulopathies represent a broad category of diseases that affect blood clotting, which can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies a…

Factor VIII Deficiency, Hemophilia A
(F8 Exon 1, Shepherd Variant 2)
Blood

Coagulopathies represent a broad category of diseases that affect blood clotting, which can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies a…

Canine Leukocyte Adhesion Deficiency Type III (LAD3)
(FERMT3)
Blood

A rare disorder of white blood cells, this causes increased susceptibility to infections and bleeding tendencies. Affected dogs present with a history of persistent skin …

Achromatopsia
(CNGA3 Exon 7 German Shepherd Variant)
Eyes

This is a progressive, nonpainful disorder of the retina that affects color vision and light perception. Cone cells not only register color, they allow the dog to adjust …

X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia
(EDA Intron 8)
Multisystem

This developmental condition can cause a scanty haircoat, malformed teeth, and few or absent sweat glands. Because dogs only have sweat glands on their paw pads, they are…

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)
(FLCN Exon 7)
Multisystem

A multiorgan syndrome best described in the German Shepherd Dog, affected dogs display thick skin nodules and signs of kidney disease, and should be evaluated by a veteri…

Mucopolysaccharidosis Type VII, Sly Syndrome
(GUSB Exon 3)
Multisystem

A type of lysosomal storage disease, this can cause skeletal abnormalities, growth retardation, and gait abnormalities, and can require close monitoring and special measu…

Degenerative Myelopathy
(SOD1A)
Brain and Spinal Cord

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

Malignant Hyperthermia
(RYR1)
Metabolic

This condition only manifests if affected dogs are treated with certain inhalant anesthetics, and can cause uncontrollable muscle contractions and a dangerous increase in…

Other Conditions: Clear of 155

Nala Blue is clear of 155 other genetic diseases that Embark tests for.

Explore more

Swipe left and right to explore more results, or choose a category below

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Nala Blue.

Maternal Haplotype

>
Through the DNA inherited from Nala Blue’s mother we can trace her ancestry back to where dogs and people first became friends. Find out how far Nala Blue’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Nala Blue’s DNA includes a story of where her father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Nala Blue find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Coat Color

A number of genetic loci are known to affect coat color in dogs, and they all interact. In some cases, other genetic effects may also influence color and pattern.

Some other Embark dogs with this Coat Color genotype:

E Locus (Mask, Grizzle, Recessive Red)
EmEm
Chromosome 5

Controls the characteristic melanistic mask seen in the German Shepherd and Pug as well as the grizzled "widow's peak" of the Afghan and Borzoi. Melanistic mask (Em) is dominant to grizzle (Eg) which is dominant to black (E) and red (e). Dogs that are EE or Ee are able to produce normal black pigment, but its distribution will be dependent on the genotypes at the K and A Loci. Dogs that are ee will be a shade of red or cream regardless of their genotype at K and A. The shade of red, which can range from a deep copper like the Irish Setter to the near-white of some Golden Retrievers, is dependent on other genetic factors including the Intensity (I) Locus, which has yet to be genetically mapped.

Want to help us map I Locus? If you haven't already, complete your ee pup's Embark profile with a photo! Remember, a picture is worth a thousand words!

Citations: Schmutz et al 2003 , Dreger and Schmutz 2010 ,

More information: http://www.doggenetics.co.uk/masks.html

K Locus (Dominant Black)
kyky
Chromosome 16

Causes a dominant black coat. Dogs with a dominant KB allele have black coats regardless of their genotype at the A locus; the coat color of dogs homozygous for the recessive ky allele are controlled by A locus. Alleles: KB > ky

Citations: Candille et al 2007

More information: http://www.doggenetics.co.uk/black.htm

A Locus (Agouti, Sable)
awat
Chromosome 24

Determines whether hair pigment is produced in a banded red and black pattern or solid black. Fawn or sable (ay) is dominant to wolf sable (aw) which is dominant to black-and-tan (at), which is in turn dominant to recessive black (a).

Citations: Berryere et al 2005 , Dreger and Schmutz 2011 ,

More information: http://www.doggenetics.co.uk/tan.html

D Locus (Dilute, Blue, Fawn)
DD
Chromosome 25

Lightens a black coat to blue and a red coat to buff. A dilute phenotype requires two copies of the recessive d allele.

Citations: Drogemuller et al 2007

More information: http://www.doggenetics.co.uk/dilutes.html

B Locus (Brown, Chocolate, Liver, Red)
BB
Chromosome 11

Lightens a black coat to brown, chocolate or liver. The brown phenotype requires two copies of the recessive b allele. Red or cream dogs that carry two b alleles remain red or cream but have brown noses and footpads.

Citations: Schmutz et al 2002

More information: http://www.doggenetics.co.uk/liver.html

Other Coat Traits

Furnishings, shedding and curls are all genetic! And they all interact, too. In fact, the combination of these genetic loci explain the coat phenotypes of 90% of AKC registered dog breeds.

For more information on the genetics of coat types you can refer to https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897713/figure/F3/

Some other Embark dogs with this Coat Traits genotype:

Furnishings / Improper Coat (RSPO2)
II
Chromosome 13

Confers the distinguished moustache, beard, and eyebrows characteristic of breeds like the Schnauzer, Scottish Terrier, and Wire Haired Dachshund; only one copy of the dominant F allele is required for furnishings. The FI genotype is furnished but carries one allele for no furnishings, or improper coat. A dog with two I alleles has improper coat. The mutation is a 167-bp insertion which we measure indirectly using linked markers highly correlated with the insertion.

Citations: Cadieu et al 2010

Long Haircoat (FGF5)
GT
Chromosome 32

The FGF5 gene is known to affect hair length in many different species, including cats, dogs, mice, and humans! The "T" allele confers a long, silky haircoat as observed in the Yorkshire Terrier and the Long Haired Whippet. The ancestral "G" allele causes a shorter coat as seen in the Boxer or the American Staffordshire Terrier.

Citations: Housley & Venta 2006 , Cadieu et al 2010

Shedding (MC5R)
CC
Chromosome 1

Affects shedding propensity in non-wire-haired dogs. Dogs with the ancestral C allele, like many Labradors and German Shepherd Dogs, are heavy or seasonal shedders, while those with one or more T allele, including many Boxers, Shih Tzus and Chihuahuas, tend to be low shedders. Dogs with furnished/wire-haired coats tend to be low shedders regardless of their MC5R genotype.

Citations: Hayward et al 2016

Curly Coat (KRT71)
CC
Chromosome 27

Causes the curly coat characteristic of Poodles and Bichons Frises. Dogs need at least one copy of the "T" allele to have a wavy or curly coat; the ancestral "C" allele is associated with a straight coat.

Citations: Cadieu et al 2010

Other Body Features

Brachycephaly (BMP3)
CC
Chromosome 32

Affects skull size and shape. Many brachycephalic or "smushed face” breeds such as the English Bulldog, Pug, and Pekingese have two copies of the derived A allele. Mesocephalic (Staffordshire Terrier, Labrador) and dolichocephalic (Whippet, Collie) dogs have one, or more commonly two, copies of the ancestral C allele. At least five different genes affect snout length in dogs, with BMP3 being the only one with a known causal mutation. For example, the skull shape of some breeds, including the dolichocephalic Scottish Terrier or the brachycephalic Japanese Chin, appear to be caused by other genes.

Citations: Schoenbeck et al 2012

Natural Bobtail (T)
CC
Chromosome 1

Whereas most dogs have two C alleles and a long tail, dogs with one G allele are likely to have a bobtail, which is an unusually short or absent tail. This mutation causes natural bobtail in many breeds including the Pembroke Welsh Corgi, the Australian Shepherd, and the Brittany Spaniel. Dogs with GG genotypes have not been observed, suggesting that the GG genotype results in embryonic lethality.

Please note that this mutation does not explain every natural bobtail! While certain lineages of Boston Terrier, English Bulldog, Rottweiler, Miniature Schnauzer, Cavalier King Charles Spaniel, and Parson Russell Terrier, and Dobermans are born with a natural bobtail, these breeds do not have this mutation. This suggests that other unknown genetic mutations can also lead to a natural bobtail. If your dog does not have a CG genotype but was born with a bobtail, please email us at howdy@embarkvet.com!

Citations: Haworth et al 2001 , Hytonen et al 2009

Hind Dewclaws (LMBR1)
CC
Chromosome 16

Common in certain breeds, hind dewclaws are extra, nonfunctional digits located midway between your dog's paw and hock. Dogs with at least one copy of the T allele have about a 50% of chance of having hind dewclaws.

Citations: Park et al 2008

Body Size

Body size is a complex trait that is affected by both genetic and environmental variation. Our genetic analysis includes genes that, together, explain over 80% of the variation in dog body size. It does not account for runting or stunting; nor does it account for the interactions between various genes both known and unknown.

Some other Embark dogs with this Body Size genotype:

Body Size - IGF1
NN
Chromosome 15

The "I" allele is associated with smaller size.

Citations: Sutter et al 2007

Body Size - IGF1R
GG
Chromosome 3

The "A" allele is associated with smaller size.

Citations: Hoopes et al 2012

Body Size - STC2
TT
Chromosome 4

The "A" allele is associated with smaller size.

Citations: Rimbault et al 2013

Body Size - GHR (E195K)
GG
Chromosome 4

The "A" allele is associated with smaller size.

Citations: Rimbault et al 2013

Body Size - GHR (P177L)
CC
Chromosome 4

The "T" allele is associated with smaller size.

Citations: Rimbault et al 2013

Performance

Altitude Adaptation (EPAS1)
GG
Chromosome 10

Confers hypoxia tolerance. Dogs with at least one A allele are more tolerant of high altitude environments. This mutation was originally identified in breeds from high altitude areas such as the Tibetan Mastiff.

Citations: Gou et al 2014

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Nala Blue for over 160 genetic health conditions to alert her owner to potential issues before they strike.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Nala Blue.

Maternal Haplotype

>
Through the DNA inherited from Nala Blue’s mother we can trace her ancestry back to where dogs and people first became friends. Find out how far Nala Blue’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Nala Blue’s DNA includes a story of where her father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Nala Blue find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

DNA shows us the unique path to each of today’s recognized breeds by exposing the relatedness between them.

Some images and text courtesy of the AKC, used with permission.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Nala Blue for over 160 genetic health conditions to alert her owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Maternal Haplotype

>
Through the DNA inherited from Nala Blue’s mother we can trace her ancestry back to where dogs and people first became friends. Find out how far Nala Blue’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Nala Blue’s DNA includes a story of where her father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Nala Blue find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Through Nala Blue’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C27

Map

C1

Nala Blue von WinterKommT’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C27

Nala Blue von WinterKommT’s Haplotype

Part of the C1 haplogroup, this haplotype occurs most commonly in German Shepherd Dogs, Labrador Retrievers, Siberian Huskies, and village dogs from Peru and Croatia.

Some other Embark dogs with this haplotype:

The C1 maternal line is commonly found in Jackals.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Nala Blue for over 160 genetic health conditions to alert her owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Nala Blue.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Nala Blue’s DNA includes a story of where her father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Nala Blue find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

This 'Paternal Haplotype' tab is for deep ancestral lineage going back thousands of years.

For recent ancestry—"What breeds did my dog inherit from her mom and dad?"—please refer to the Breed or Summary tab and the Family Tree tab.

The Paternal Haplotype refers to a dog’s deep ancestral lineage stretching back thousands of years, before there were any distinct breeds of dog. We determine the Paternal Haplotype by looking at a dog’s Y-chromsome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Nala Blue is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Nala Blue for over 160 genetic health conditions to alert her owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Nala Blue.

Maternal Haplotype

>
Through the DNA inherited from Nala Blue’s mother we can trace her ancestry back to where dogs and people first became friends. Find out how far Nala Blue’s family has traveled.

What’s your dog’s story?

Now that you have explored what’s behind Nala Blue find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!