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“Stella”
Blossom Valley Got Her Groove Back

Labrador Retriever

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“Stella is a black Lab girl that I received as a puppy back from a stud service of her sire Cabo. Her dam is an avid hunter. In 2020, Stella's Embark testing shows she is clear of everything except EIC for which she is a carrier. OFA hips Excellent, OFA elbows normal, and OFA eyes normal. Bred chocolate stud, Cedar Ranch Porter Maddox of B&B, she produced a litter on 12/7/20: 6 chocolates (5 boys and 1 girl) and 3 blacks (2 girls and 1 boy). All are healthy happy Labrador puppies!”

Place of Birth

El Cajon, CA, USA

Current Location

Aguanga, California, USA

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Registration

American Kennel Club (AKC): SS06491302
Microchip: 95600 00119 20589

Genetic Breed Result

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Labrador Retriever

The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.

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Genetic Stats

Predicted Adult Weight

53 lbs

Genetic Age
37 human years

Based on the date of birth provided

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Health Summary

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Stella inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Exercise-Induced Collapse, EIC

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Stella inherited one copy of the variant we tested

What does this result mean?

This result should not impact Stella’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

ALT Activity

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Stella inherited one copy of the variant we tested

Why is this important to your vet?

Stella has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Stella has this genotype, as ALT is often used as an indicator of liver health and Stella is likely to have a lower than average resting ALT activity. As such, an increase in Stella’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Canine Elliptocytosis (SPTB Exon 30)

Identified in Labrador Retrievers

Pyruvate Kinase Deficiency (PKLR Exon 7, Labrador Retriever Variant)

Identified in Labrador Retrievers

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Labrador Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)

Identified in Labrador Retrievers

Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Labrador Retrievers

Day Blindness (CNGA3 Exon 7, Labrador Retriever Variant)

Identified in Labrador Retrievers

Macular Corneal Dystrophy, MCD (CHST6)

Identified in Labrador Retrievers

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Labrador Retrievers

Alexander Disease (GFAP)

Identified in Labrador Retrievers

Narcolepsy (HCRTR2 Intron 6, Labrador Retriever Variant)

Identified in Labrador Retrievers

Centronuclear Myopathy, CNM (PTPLA)

Identified in Labrador Retrievers

X-Linked Myotubular Myopathy (MTM1, Labrador Retriever Variant)

Identified in Labrador Retrievers

Congenital Myasthenic Syndrome, CMS (COLQ, Labrador Retriever Variant)

Identified in Labrador Retrievers

Hereditary Nasal Parakeratosis, HNPK (SUV39H2)

Identified in Labrador Retrievers

Skeletal Dysplasia 2, SD2 (COL11A2, Labrador Retriever Variant)

Identified in Labrador Retrievers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (EmEm)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBKB)
Intensity Loci LINKAGE
No impact on coat pattern (Intermediate Red Pigmentation)
A Locus (ASIP)
Not expressed (atat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (Bb)
Saddle Tan (RALY)
Not expressed (II)
S Locus (MITF)
Likely to have little to no white in coat (SS)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely heavy/seasonal shedding (CT)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Smaller (II)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Stella’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A400

Map

A1a

Blossom Valley Got Her Groove Back’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A400

Blossom Valley Got Her Groove Back’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Stella inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Stella is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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