Bella O’Sage inherited one copy of the variant we tested
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“Sweet tempered calm red and white parti”
Place of Birth
Michigan, USA
Current Location
Alabama, USA
From
Michigan, USA
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Health Summary
Bella O’Sage is at increased risk for one genetic health condition.
And inherited two variants that you should learn more about.
Intervertebral Disc Disease (Type I)
How to interpret this result
Bella O’Sage has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.
What is Intervertebral Disc Disease (Type I)?
Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.
Progressive Retinal Atrophy, prcd
Bella O’Sage inherited one copy of the variant we tested
What does this result mean?
This variant should not impact Bella O’Sage’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Bella O’Sage is unlikely to develop this condition due to this variant because she only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Progressive Retinal Atrophy, prcd?
PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
ALT Activity
Bella O’Sage inherited one copy of the variant we tested
Why is this important to your vet?
Bella O’Sage has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Bella O’Sage has this genotype, as ALT is often used as an indicator of liver health and Bella O’Sage is likely to have a lower than average resting ALT activity. As such, an increase in Bella O’Sage’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
Von Willebrand Disease Type I, Type I vWD (VWF)
Identified in Standard Poodles and Small Poodles
Variant not detected
Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1 (SLC4A3)
Identified in Golden Retrievers
Variant not detected
Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)
Identified in Golden Retrievers
Variant not detected
Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)
Identified in English Springer Spaniels
Variant not detected
Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)
Identified in Cocker Spaniels
Variant not detected
Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)
Identified in Cocker Spaniels and English Springer Spaniels
Variant not detected
Neuronal Ceroid Lipofuscinosis 5, NCL 5 (CLN5 Exon 4 Deletion, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
GM2 Gangliosidosis (HEXB, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Degenerative Myelopathy, DM (SOD1A)
Identified in English Springer Spaniels, Golden Retrievers, and more
Variant not detected
Shaking Puppy Syndrome (PLP1, English Springer Spaniel Variant)
Identified in English Springer Spaniels
Variant not detected
Neonatal Encephalopathy with Seizures, NEWS (ATF2)
Identified in Standard Poodles and Small Poodles
Variant not detected
Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)
Identified in Cocker Spaniels and English Springer Spaniels
Variant not detected
Long QT Syndrome (KCNQ1)
Identified in English Springer Spaniels
Variant not detected
Muscular Dystrophy (DMD, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Exercise-Induced Collapse, EIC (DNM1)
Identified in Cocker Spaniels
Variant not detected
Dystrophic Epidermolysis Bullosa (COL7A1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Ichthyosis, ICH1 (PNPLA1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Osteogenesis Imperfecta (COL1A1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Osteochondrodysplasia (SLC13A1, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.