Bella inherited one copy of the variant we tested
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@mulemountaindoodles
Place of Birth
Mule Mountain Doodles, West Florimond Road, Phoenix, AZ, USA
Current Location
Glendale, Arizona, USA
From
Mule Mountain Doodles, West Florimond Road, Phoenix, AZ, USA
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Health Summary
Bella inherited one variant that you should learn more about.
And one variant that you should tell your vet about.
Degenerative Myelopathy, DM
What does this result mean?
This variant should not impact Bella’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Bella is unlikely to develop this condition due to this variant because she only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
ALT Activity
Bella inherited one copy of the variant we tested
Why is this important to your vet?
Bella has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Bella has this genotype, as ALT is often used as an indicator of liver health and Bella is likely to have a lower than average resting ALT activity. As such, an increase in Bella’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
Von Willebrand Disease Type I, Type I vWD (VWF)
Identified in Standard Poodles and Small Poodles
Variant not detected
Progressive Retinal Atrophy, prcd (PRCD Exon 1)
Identified in Cocker Spaniels, Standard Poodles, and more
Variant not detected
Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)
Identified in Cocker Spaniels
Variant not detected
Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)
Identified in Cocker Spaniels
Variant not detected
GM2 Gangliosidosis (HEXB, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Neonatal Encephalopathy with Seizures, NEWS (ATF2)
Identified in Standard Poodles and Small Poodles
Variant not detected
Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)
Identified in Cocker Spaniels
Variant not detected
Exercise-Induced Collapse, EIC (DNM1)
Identified in Cocker Spaniels
Variant not detected
Osteochondrodysplasia (SLC13A1, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)
Identified in Cocker Spaniels, Standard Poodles, and more
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.