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“Augie”
Sir August of Topknot

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Changes to this dog’s profile
  • On 11/3/2023 changed name from "Augie" to "Sir August of Topknot"

Health Summary

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Augie inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Proportionate Dwarfism

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Augie inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Augie’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Augie is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Proportionate Dwarfism?

Embark’s data suggests that this variant in the GH1 gene may contribute to a smaller body size. The original publication predicts this is due to a growth hormone (GH) deficiency. However, adult body size is influenced by several different genetic variants. Other changes noted by the publication, including retained baby teeth, persistent puppy-like coats, and low blood sugar have been occasionally reported by owners of dogs with two copies of this variant. These changes may or may not be associated with this variant.

ALT Activity

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Augie inherited both copies of the variant we tested

Why is this important to your vet?

Augie has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Augie's ALT activity above their current, healthy, ALT activity. As an increase above Augie’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Biewer Terriers

Primary Lens Luxation (ADAMTS17)

Identified in Biewer Terriers

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Havaneses

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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