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“Athena”
Louttit’s Green Mountain Athena

English Shepherd

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“Protective, with a Therapy/Family temperament”

Place of Birth

North Carolina, USA

Current Location

Torquay, SK, Canada

From

North Carolina, USA

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Registration

English Shepherd Club (ESC): ESC-1822

Genetic Breed Result

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English Shepherd

A farmer's helper, a loyal companion, a child's shadow: The English Shepherd.

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Changes to this dog’s profile
  • On 6/21/2020 changed name from "Athena" to "Louttit’s Green Mountain Athena"

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Athena’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Athena is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Multiple Drug Sensitivity

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Athena inherited one copy of the variant we tested

How to interpret this result

Athena has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Athena. Please inform your veterinarian that Athena carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

Degenerative Myelopathy, DM

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Athena inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Athena is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Athena inherited one copy of the variant we tested

Why is this important to your vet?

Athena has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Athena has this genotype, as ALT is often used as an indicator of liver health and Athena is likely to have a lower than average resting ALT activity. As such, an increase in Athena’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Trapped Neutrophil Syndrome, TNS (VPS13B)

Identified in English Shepherds

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in English Shepherds

Collie Eye Anomaly (NHEJ1)

Identified in English Shepherds

Urate Kidney & Bladder Stones (SLC2A9)

Identified in English Shepherds

Additional Genetic Conditions

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Coat Color

Coat Color

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Other Coat Traits

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Body Size

Performance

Performance

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Through Athena’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B43

Map

B1

Louttit’s Green Mountain Athena’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B43

Louttit’s Green Mountain Athena’s Haplotype

Part of the large B1 haplogroup, we have spotted this haplotype in Havanese, Cocker Spaniels, and village dogs in Mexico.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Athena inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Athena is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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