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ASH

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Genetic Breed Result

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65.7% Gray Wolf
9.3% Alaskan Malamute
8.5% German Shepherd Dog
6.8% Siberian Husky
9.7% Unresolved

Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

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Genetic Stats


Predicted Adult Weight
Genetic Age
28 human years Learn More
Based on the date of birth provided

DNA Breed Origins

What’s this?
Breed colors:
Gray Wolf
Alaskan Malamute
German Shepherd Dog
Siberian Husky
Unresolved

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Health Summary

ASH inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

2-DHA Kidney & Bladder Stones

ASH inherited one copy of the variant we tested

What does this result mean?

This result should not impact ASH’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

This result should be taken into account as part of your breeding program. ASH will pass this variant to ~50% of his offspring.

What is 2-DHA Kidney & Bladder Stones?

This condition causes 2,8-dihydroxyadenine (2,8-DHA) kidney and bladder stones.


ALT Activity

ASH inherited one copy of the variant we tested

Why is this important to your vet?

ASH has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that ASH has this genotype, as ALT is often used as an indicator of liver health and ASH is likely to have a lower than average resting ALT activity. As such, an increase in ASH’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

Multiple Drug Sensitivity (MDR1)

Identified in German Shepherd Dogs

Factor VII Deficiency (F7 Exon 5)

Identified in Alaskan Malamutes

Hemophilia A (F8 Exon 11, Shepherd Variant 1)

Identified in German Shepherd Dogs

Hemophilia A (F8 Exon 1, Shepherd Variant 2)

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLADIII (FERMT3)

Identified in German Shepherd Dogs

Day Blindness (CNGA3 Exon 7 German Shepherd Variant)

Identified in German Shepherd Dogs

Urate Kidney & Bladder Stones (SLC2A9)

Identified in German Shepherd Dogs

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3)

Identified in German Shepherd Dogs

GM1 Gangliosidosis (GLB1 Exon 15 Alaskan Husky Variant)

Identified in Siberian Huskies

Degenerative Myelopathy, DM (SOD1A)

Identified in German Shepherd Dogs

Polyneuropathy, NDRG1 Malamute Variant (NDRG1 Exon 4)

Identified in Alaskan Malamutes

Additional Genetic Conditions

Through ASH’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A388

Map

A1a

ASH’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A388

ASH’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Staffordshire Terriers, Labrador Retrievers, and English Bulldogs.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

Through ASH’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B1.2

Map

B1

ASH’s Haplogroup

This is a lineage that is found infrequently in dogs and may only be found in gray wolves and dogs with recent wolf ancestors. It is very different from all known dog lineages indicating a long time between the most recent common ancestor of canids in this lineage and domestic dogs.

B1.2

ASH’s Haplotype

This haplotype has been spotted in wolves and dogs with wolf ancestry. Not only is that pretty neat, but it also helps move science forward.

Some other Embark dogs with this haplotype:

The mysterious wolf hides many genetic mysteries unknown to science - like where this male lineage came from.