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Ash

Australian Shepherd Group

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Registration

American Stock Dog Registry (ASDR): ASDM-ID-2101077

Genetic Breed Result

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Miniature/MAS-type Australian Shepherd

Miniature American Shepherds (also known as Miniature Australian Shepherds, or Mini Aussies) have the trainability, intelligence and energy of the larger Aussie cousins, and excel at outdoors activities and agility competitions.

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DNA Breed Origins

Breed colors:
Miniature/MAS-type Australian Shepherd

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Health Summary

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Ash inherited two variants that you should learn more about.

And one variant that you should tell your vet about.

Progressive Retinal Atrophy, prcd

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Ash inherited one copy of the variant we tested

What does this result mean?

This result should not impact Ash’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Progressive Retinal Atrophy, prcd?

PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.

Dilated Cardiomyopathy, DCM1

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Ash inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Ash will develop this condition.

Scientific Basis

Dogs with Ash’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Ash developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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Ash inherited one copy of the variant we tested

Why is this important to your vet?

Ash has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Ash has this genotype, as ALT is often used as an indicator of liver health and Ash is likely to have a lower than average resting ALT activity. As such, an increase in Ash’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Collie Eye Anomaly (NHEJ1)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Hereditary Cataracts (HSF4 Exon 9, Australian Shepherd Variant)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Neuronal Ceroid Lipofuscinosis 6, NCL 6 (CLN6 Exon 7, Australian Shepherd Variant)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8, Australian Shepherd Variant)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Craniomandibular Osteopathy, CMO (SLC37A2)

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Ash’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B61

Map

B1

Ash’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B61

Ash’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most commonly in Australian Cattle Dogs. It’s a rare find!

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Ash inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Ash is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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