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“Amara”
Amara

Australian Shepherd Group

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“Tested and owned by Samantha Pollzzie”

Place of Birth

Fresno, California, USA

Current Location

Pemberville, Ohio, USA

From

Fresno, California, USA

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Registration

American Stock Dog Registry (ASDR):

Genetic Breed Result

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Australian Shepherd

Australian Shepherds are an energetic mid-sized breed that make the perfect companion.

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Genetic Stats

Predicted Adult Weight

40 lbs

Genetic Age
46 human years

Based on the date of birth provided

DNA Breed Origins

Breed colors:
Australian Shepherd

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Health Summary

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Amara is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

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Amara inherited one copy of the variant we tested

How to interpret this result

Amara has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Amara. Please inform your veterinarian that Amara carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

ALT Activity

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Amara inherited one copy of the variant we tested

Why is this important to your vet?

Amara has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Amara has this genotype, as ALT is often used as an indicator of liver health and Amara is likely to have a lower than average resting ALT activity. As such, an increase in Amara’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Australian Shepherds and Australian Shepherds

Collie Eye Anomaly (NHEJ1)

Identified in Australian Shepherds and Australian Shepherds

Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in Australian Shepherds and Australian Shepherds

Hereditary Cataracts (HSF4 Exon 9, Australian Shepherd Variant)

Identified in Australian Shepherds and Australian Shepherds

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Australian Shepherds and Australian Shepherds

Neuronal Ceroid Lipofuscinosis 6, NCL 6 (CLN6 Exon 7, Australian Shepherd Variant)

Identified in Australian Shepherds and Australian Shepherds

Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8, Australian Shepherd Variant)

Identified in Australian Shepherds and Australian Shepherds

Craniomandibular Osteopathy, CMO (SLC37A2)

Identified in Australian Shepherds and Australian Shepherds

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

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Body Size

Performance

Performance

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Through Amara’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A604

Map

A1d

Amara’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A604

Amara’s Haplotype

Part of the A1d haplogroup, the A604 haplotype occurs most commonly in Australian Shepherds. It's a rare find!

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Amara inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Amara is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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