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“Amando”
Alse'Amando Del Lorenzo Vicale

Lagotto Romagnolo

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“Loves everyone, playful, smart, inventive.”

Place of Birth

Waldport, OR, USA

Current Location

Waldport, OR, USA

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Registration

American Kennel Club (AKC): SS 27145201

Genetic Breed Result

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Lagotto Romagnolo

Lagotto Romagnolos are an Italian breed of dog from the Romagna region of Italy. Sporting curly hair and charming faces, they were originally bred as hunting dogs during the Medieval Period; however, today they are mostly kept as pets and as a different kind of hunting dog—Lagotto Romagnolos are expert truffle dogs. Their wonderful sense of smell makes them a great candidate for finding and unearthing truffles, rare and expensive mushrooms that are considered culinary delicacies.

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Health Summary

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Amando is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Amando inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Amando’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Amando have not yet been the focus of research studies, our data indicates that Amando is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Amando’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Degenerative Myelopathy, DM

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Amando inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Amando is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Amando inherited one copy of the variant we tested

Why is this important to your vet?

Amando has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Amando has this genotype, as ALT is often used as an indicator of liver health and Amando is likely to have a lower than average resting ALT activity. As such, an increase in Amando’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Urate Kidney & Bladder Stones (SLC2A9)

Identified in Lagotto Romagnolos

Lagotto Storage Disease (ATG4D)

Identified in Lagotto Romagnolos

Juvenile Epilepsy (LGI2)

Identified in Lagotto Romagnolos

Additional Genetic Conditions

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Through Amando’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A11a/419

Map

A1d

Alse'Amando Del Lorenzo Vicale’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A11a/419

Alse'Amando Del Lorenzo Vicale’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in Yorkshire Terriers, Old English Sheepdogs, and Miniature Schnauzers.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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Through Amando’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.9

Map

A2b

Alse'Amando Del Lorenzo Vicale’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.9

Alse'Amando Del Lorenzo Vicale’s Haplotype

Part of the A2b haplogroup, this haplotype is found in village dogs spanning South America, Africa, and the South Pacific. Among the breeds we have spotted it in, the most frequent occurrences are in Dachshund, Bloodhound, American Eskimo Dog, and Jack Russell Terrier.

Some other Embark dogs with this haplotype:

A2b is found in the Daschund breed.

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