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“Tyyne”
Afrodite di Meillon

Doberman Pinscher

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Place of Birth

Italia

Current Location

Ruotsi

From

Italia

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Registration

Fédération Cynologique Internationale (FCI): SE16113/2017

Genetic Breed Result

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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Genetic Stats

Predicted Adult Weight

78 lbs

Genetic Age
59 human years

Based on the date of birth provided

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Health Summary

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Tyyne inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Von Willebrand Disease Type I, Type I vWD

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Tyyne inherited one copy of the variant we tested

What does this result mean?

This result should not impact Tyyne’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Von Willebrand Disease Type I, Type I vWD?

Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.

ALT Activity

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Tyyne inherited one copy of the variant we tested

Why is this important to your vet?

Tyyne has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Tyyne has this genotype, as ALT is often used as an indicator of liver health and Tyyne is likely to have a lower than average resting ALT activity. As such, an increase in Tyyne’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM1 (PDK4, Doberman Pinscher Variant 1)

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM2 (TTN, Doberman Pinscher Variant 2)

Identified in Doberman Pinschers

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Tyyne’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C38

Map

C1

Afrodite di Meillon’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C38

Afrodite di Meillon’s Haplotype

Part of the C1 haplogroup, this haplotype occurs most frequently in Doberman Pinschers and Black Russian Terriers.

Some other Embark dogs with this haplotype:

The C1 maternal line is commonly found in Jackals.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Tyyne inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Tyyne is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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